Apart from biomarker discovery, lipidomics could help to reveal the pathogenesis related to cancer. Till now, numerous studies have shown that de novo FA synthesis was a critical regulator of cancer growth. Here are some studies.
- The sole carbon source and precursor for both FA and cholesterol biosynthesis in mammalian cells is acetyl-CoA. The study revealed that the activity of acetyl-CoA synthetase 2, an enzyme that converts acetate to acetyl-CoA, contributed to cancer cell growth under low-oxygen and lipid-depleted conditions by enhancing the ability of cancer cells to use acetate as an additional nutritional source. It was a potential molecular target for managing cancer growth.
- PLs also play an important role in cancer. Two of the most commonly activated pathways in human cancer are the PI3K‐Akt and the Ras pathways. A study investigated the function of individual PL in cell cycle regulation, showing that 20:4‐PC oscillates during the cell cycle and delays cell cycle progression by inhibiting Akt membrane binding.
Fig1. Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth (Schug.; et al, 2015)
With extensive experience and state-of-the-art technologies, Creative Proteomics offers cutting-edge mass spectrometry (MS)-based lipidomics services, including Untargeted Lipidomics Services, Targeted Lipidomcs Services, Metabolic flux Analysis Services for Cancer Pathogenesis Research.
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- Liquid chromatography hyphenated to high resolution /high accuracy mass spectrometry for untargeted lipidomics
Waters ACQUITY UPLC H Class Plus System + Waters Xevo G2-XS QTof Mass Spectrometry;
Waters ACQUITY UPLC H Class Plus System + Thermo Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer;
Shimadzu Nexera X2 U-HPLC System + Thermo Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer;
Waters ACQUITY UPLC H Class Plus System + Waters SYNAPT G2-Si HDMS+ Waters Xevo G2-XS QTof Mass Spectrometry.
- Shotgun throughput lipidomics analysis
TriVersa Nanomate nanoelectrospray ion source+ Orbitrap instruments.
Fig2. Creative Proteomics offers cutting-edge mass spectrometry (MS)-based lipidomics services (Creative Proteomics)
- Our Lipidomics Statistics
A detailed report will be provided at the end of the whole project, including the experiment procedure, MS/MS instrument parameter, raw data and data reports with figures, ready to be published.
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References:
- Perrotti F., et al. Advances in lipidomics for cancer biomarkers discovery[J]. International journal of molecular sciences. 2016, 17(12): 1992.
- Schug.; et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer cell. 2015, 27.1: 57-71.